3/21/2024 0 Comments Cystic fibrosis lung sounds![]() aeruginosa early in the course of disease have been successful and are thought to improve prognosis significantly if sustained. aeruginosa evolves in CF lungs to adopt a mucoid phenotype (attributable to release of alginate exoproduct) that confers selective advantage for the pathogen and poor prognosis for the host. aeruginosa exhibit a stereotypic mode of pathogenesis a sentinel and early colonization event often engenders lifelong pulmonary infection by the same genetic strain. Robust pulmonary inflammation in the setting of inspissated mucus and chronic bacterial infection leads to collateral tissue injury and further aggravates respiratory decline. Microbiome analysis has identified hundreds of other bacterial species in CF lungs, although their relationship to pulmonary failure remains to be determined. CF airway secretions are exceedingly difficult to clear, and a complex bacterial flora that includes Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa (among other pathogens) is routinely cultured from CF sputum. Cystic fibrosis causes a build-up of thick mucus that blocks ducts and tubes within the lungs, bowel, and pancreas. ![]() The major morbidity and mortality associated with CF is attributable to respiratory compromise, characterized by copious hyperviscous and adherent pulmonary secretions that obstruct small and medium-sized airways. Cystic Fibrosis begins as an obstructive lung disease in which patients have difficulty pushing the air out of their lungs, this results in hyperinflation of the lungs and bronchiectasis. ![]()
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